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International Journal of Colorectal Disease , 2014

Structural modifications to IGF-1 LR3specifically the inclusion of additional amino acids at the N-terminus and a substitution at position threehave been associated with enhanced receptor affinity

Nature 387 , 206209 (1997)

Its important to note that water retention is a common side effect of many growth hormone secretagogues due to their effect on the bodys fluid balance