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When an oxidative stressor or electrophile interacts with the Keap1-Nrf2 complex, it allows for the release and subsequent nuclear accumulation of Nrf2 through a complex process of ubiquitination-inhibition, thus triggering an anti-stress response by the cell

Authors:Paix A, Wang Y, Smith HE, Lee CY, Calidas D, Lu T, Smith J, Schmidt H, Krause MW, Seydoux G, Journal: PubMed ID:25249454 Homology-directed repair (HDR) of double-strand DNA breaks is a promising method for genome editing, but is thought to be less efficient than error-prone nonhomologous end joining in most cell types

Abstract Cyclic vomiting syndrome (CVS) is a functional disorder characterized by stereotypical episodes of intense vomiting separated by weeks to months

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