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447 Interestingly, iron infusion was associated with reduced sPAP in sea-level residents exposed to acute hypoxia at 4340 m, whereas iron infusion cannot improve sPAP among CMS patients with phlebotomy

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This network includes numerous genes that exhibit circadian rhythms (Wang et al., 2017) or directly interact with components of the molecular clock, and their progressive loss of functionality contributes both to circadian disruptions and to increased accumulation of genomic damage in cells, thereby elevating the risk of cancer development (Miller et al., 2021)

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