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10.1111/j.1432-1033.1994.tb18550.x 61 MuecklerM.ThorensB

[DOI] [PMC free article] [PubMed] [Google Scholar] 76.Yang Q., Jacobs T.M., McCallen J.D., Moore D.T., Huckaby J.T., Edelstein J.N., Lai S.K

There is a detrimental impact of neutrophil-released ROS on ECs, which contributes to plaque formation and inflammation, inducing e.g., vascular hyperpermeability (Meegan et al., 2017)

They also introduced mutations that optimized the enzymes overall kinetics with the goal of driving the gluten peptide levels below the threshold for toxicity, which is estimated at 50 milligrams per day, and doing so within a physiologically relevant timeframe (7)