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Future studies should investigate how to intervene in the progression of atherosclerosis by modulating the complex balance of gut microbiota

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A decrease in IGF-I levels in AD and VD has been widely documented and it may be involved in the development of neurofibrillary tangles, abnormal amyloid metabolism and aberrant Tau phosphorylation, cognitive loss, neural inflammation, oxidative stress or mitochondrial dysfunction, among others[68, 325]

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