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Activation of integrin-linked kinase is a critical prosurvival pathway induced in leukemic cells by bone marrow-derived stromal cells

Similar content being viewed by others Background Glutamine is an -amino acid and is the most abundant free amino acid in the body

This effect is further compounded by the inactivation of glutathione peroxidase 4 (GPX4) as ONOO can modify the selenocysteine residue within its active site, thereby disabling the only enzyme capable of directly reducing complex lipid hydroperoxides in biological membranes