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This was a remarkable conclusion, since the actual elements of protein secondary structure were introduced in 1951 by Linus Carl Pauling (19011994) and Robert Corey (18971971), who predicted the -helix and -sheet based on the hydrogen bonding of the protein backbone (Pauling and Corey, 1951), whereas the concept of secondary structure itself was formalized by Kaj Ulrik Linderstrm-Lang (18961959) in 1952 (Linderstrm-Lang, 1952)

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Glucocorticoid antagonists can reduce these levels, indicating that controlling the HPA axis can improve depression (315)