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In patients with critical peripheral limb ischemia (n = 10, age 68.3 3.1), a single intravenous dose of L-arginine significantly increases blood flow, accompanied by urinary cGMP excretion ( Overall , intravascular L-arginine delivery in humans offers acute improvement of endothelial function

Furthermore, it is difficult to assess the improvement of a topical agent because these are usually subtle effects that might be difficult to capture

This observation is driven by the results of the Tukey test for control samples, where statistically significant differences ( p = 0.05) were observed between the control samples and the values observed after 24 h of incubation

Consider Re-Evaluation : As the pandemic situation improves, re-evaluate if injections are a better option for long-term management.