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10.1038/nrm.2016.108 Nat Rev Mol Cell Biol

Boles published in 1997 an increased prevalence of two mitochondrial DNA polymorphisms similar to those found in migraine in patients with CVS [10] conducing them to try CVS treatment by Coenzyme Q10 (CoQ10) in association with L-carnitine and amitriptyline [11,12]

When wildtype and AQP4-deficient mice were given a low dose of the chemoconvulsant pentylenetetrazol (PTZ), it was observed that all wildtype mice exhibited seizure activity, whereas most of the AQP4-deficient mice did not produce any seizure activity (Binder et al., 2004)

In rats, curcumin replicates effects observed in mice, including reductions in serum glucose, lipid, creatinine and urea levels, and reverses proteinuria, while protecting and improving renal function [46,47,48,49,50,51,52,53,54,55,56,57]