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There is sufficient evidence that thiol containing compounds can rescue patients from acute exposure to oxidative or electrophilic stress (for example, NAC in acetaminophen overdose)

[DOI] [PubMed] [Google Scholar] [4].Sierra-Rivera ESM, Dasouki M, Krishnamani MR, Phillips JA, Freeman ML

Glutathionylation has been shown to occur on a number of proteins (Table 2) and in some cases, to alter their biological activity [21]

One recent report has shown that a down-regulation of the regulatory subunit of -GCS occurs in the rat brain during aging [100]

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