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The rapid rise in ROS tends to destroy Fe-S clusters (Balk and Schaedler, Several studies showed that SufB gene expression in Arabidopsis is down-regulated under Fe-deficient conditions (Xu et al., 2005

10.1016/j.celrep.2016.04.006

Once an antioxidant has deactivated a free radical, the damaging process is stopped in its tracks, but the antioxidant wont be able to neutralise any further free radicals

59,60 Specific genes implicated include vascular endothelial growth factor (VEGF), neurotrophic receptor tyrosine kinase 1, sodium voltage-gated channel alpha subunit 2 (SCN2A), angiotensin-converting enzyme, and methylenetetrahydrofolate reductase, with polymorphisms associated with increased DN susceptibility