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Immunological cues trigger biosynthesis of LTC 4 in mast cells by assembly of a biosynthetic complex at the nuclear envelope, consisting of cytosolic phospholipase A2 (cPLA2), 5-lipoxygenase (5-LO), 5-LO activating protein (FLAP) and LTC 4 synthase (LTC 4 S)

Human studies suggest that the dietary intake of 20 mg of niacin (or niacin equivalents) is enough to meet daily requirements [1]

TERT promoter mutation Mutations in the promoter region of the TERT gene have emerged as key molecular alterations in gliomas, influencing tumor progression, prognosis, and treatment response

This approach allows any systematic shift between methods to be seen more clearly and the bias calculated provides additional information to correlations and scatterplots alone ( Reference Dewitte, Fierens and Stockl 16 , Reference Bland and Altman 17 )