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However, GLP-1 agonists like semaglutide have more established long-term safety data

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5 Kohn, an author of this study, says men who take semaglutide are likely to see testosterone rise in the long run as they shed fat and produce less estrogen in their fat cells

In fact, it has been reported that oxidative stress induces ER stress and the unfolded protein response (UPR) in lens epithelial cells, ultimately resulting in apoptosis 44