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In addition to being part of the TCA cycle, -KG is required for the function of -KG-dependent dioxygenases, including chromatin-modifying enzymes like histone demethylases, TET family of enzymes that are involved in DNA demethylation, and PHD enzymes

Some researchers even speculate that the danger of superoxide is not in itself, but in the many other free radical compounds it so readily converts to