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Studies of this phenomenon have been hampered by the challenge of identifying patient populations that consistently have low glutathione levels

5.5 Lactate accumulation: acidification and inhibition of antitumor immunity In the complex, dynamic tumor microenvironment of colorectal cancer, metabolic reprogramming of cancer cellsparticularly the enhanced Warburg effectserves not only as a core strategy to meet bioenergetic and biosynthetic demands but also as a key driver of immunosuppression

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