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Barriers to Drug Entry Efflux Transporters The presence of P-glycoprotein (referred to as multidrug resistance associated membrane protein) allows drugs to be transported back into the blood by ATP-dependent efflux pumps

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This dual action effectively disrupts the tumor immune microenvironment (TIME), demonstrating notable antitumor efficacy in a subcutaneous breast cancer mouse model [23]

By accurately identifying high-risk populations through patient stratification tools, this approach reduces the number needed to treat (NNT), minimizes patients' exposure to unnecessary pharmacological toxicity, and effectively lowers the population-level incidence of cardiovascular diseases, while simultaneously optimizing the allocation of healthcare resources (206)