interaction of chloroacetamide electrophiles with cellular glutathion

interaction of chloroacetamide electrophiles with cellular glutathion NCBP1 stress signaling drives alternative S6K1 splicing inhibiting translation Discovery of novel benzylaniline derivatives

Name: interaction of chloroacetamide electrophiles with cellular glutathion NCBP1 stress signaling drives alternative S6K1 splicing inhibiting translation Discovery of novel benzylaniline derivatives
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Discovery of novel benzylaniline derivatives containing chloroacetamide as GPX4 inhibitors with potential efficacy in triple negative breast cancer ScienceDirect Identification, optimization, and structural elucidation of chloroacetamide scaffold as covalent inhibitors for Ubiquitin C terminal Hydrolase L3 bioRxiv Electrophilic compound screening identifies GPX4 dependent ferroptosis as a senescence vulnerability Nature Cell Biology Glutathione Transferases: Potential Targets to Overcome Chemoresistance in Solid Tumors

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Many people with depression, especially those who have experienced early childhood stress, have been found to have increased signaling along the hypothalamic-pituitary-adrenal (HPA) axis