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Interestingly, the structure of a base excision repair polymerase in complex with the N 2 -dG adduct of the benzo[ c ]phenanthrene (BPh) diol epoxide also shows the adduct in a similar conformation as in free DNA 58

Yet differential expression of components of the processes in particular neuronal systems may account for selective neurodegeneration in certain disorders. In short, the same pathological process can result in a different constellation of symptoms and therefore result in a range of eventual diagnoses