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Follicular helper T cell signature in type 1 diabetes

doi: 10.3233/JAD-160278

Recent research data has shown that the expression of lipid metabolism genes adiponectin (APN), Adipo R, AMPK, PPAR mRNA and protein is significantly increased after 48 hours of treatment with different concentrations of GLP-1 compared with the model group of adipose hepatocytes [108]

When levels of ROS/RNS rise, these molecules are capable of oxidizing the FeS cluster in active m-aconitase, causing the loss of the labile Fe atom and enzyme inactivation [74]