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Spinal cord or dorsal root ganglion stimulation may cause infection, lead migration, uncomfortable stimulation, hardware failure, loss of benefit, bleeding, and the need for reprogramming, revision, or device removal

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This characteristic renders PPAR agonists potentially applicable to patients with GA and hyperuricemia associated with cyclic FA disorders (127, 128), which reduce FA levels by suppressing lipolysis and do not selectively regulate specific types of FAs, and may, therefore, be applicable for the prevention and treatment of patients at risk of elevated circulating FA levels

Upon undertaking further investigations to determine the factors mediating these changes, the investigators found that baseline white adipose tissue IL-1beta secretion accounted for much of the association between apoB and several diabetes-related traits, and these links were lost after omega-3 supplementation