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As monotherapy , a multicentre, randomised, double-blind, placebo-controlled and active-controlled Phase 2 dose-finding trial enrolled 706 adults with overweight or obesity (without diabetes) to once-weekly subcutaneous cagrilintide across doses of 0.3 to 4.5 mg over 26 weeks

Cell Death Dis (2021) 12(10):925

Intestinal permeability and inflammatory features of juvenile age correlate with the eventual systemic autoimmunity in lupus-prone female SWR NZB F1 (SNF1) mice

547 The Phase III trial of olpasiran aims to compare its effects with the placebo on the risk of coronary heart disease death, myocardial infarction, and urgent coronary revascularization in ASCVD patients with elevated Lp(a), with results expected by 2026 (NCT05581303)