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Vitamin B12 Deficiency Symptoms Signs and symptoms of megaloblastic anemia and a B12 deficiency include: Balance issues Confusion Constipation Dementia Depression Difficulty maintaining balance Fatigue Loss of appetite Numbness and tingling in the hands and feet Poor memory Soreness of the mouth or tongue Weakness Weight loss In infants, signs of a vitamin B12 deficiency include: Delays in development Failure to thrive Megaloblastic anemia Mobility and movement issues If you are at risk of vitamin B12 deficiency, monitor your health carefully and look for signs and symptoms of low vitamin B12

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