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Identification of metabolites reproducibly associated with Parkinsons Disease via meta-analysis and computational modelling

The GSH:GSSG ratio is a widely used biomarker of cellular oxidative stress, with depletion implicated in neurodegeneration, hepatic injury, and immune dysfunction

4 Thus, as we already emphasized, 4 it follows that these two concepts have very close interconnections, and thereby, both merit common solution

Purine pathway The purine metabolites HX and XAN and the ratio XAN/XANTH were decreased significantly, while the ratios PXAN/XAN and URIC/XAN were elevated at 8 weeks compared with baseline, indicating a similar decline in the canonical pathway of purine metabolism, as observed in the tryptophan and tyrosine pathways