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Published data suggest that many candidate drugs from traditional herbal sources exert anti-inflammatory effects by inhibiting upstream signals of NLRP3, including TXNIP and NF-B, or by combating oxidative stress, such as promoting Nfr2 signal transduction

The real risks come from non-prescribed whitening creams that contain harmful ingredients like steroids, mercury, or high-dose hydroquinone

Watanabe et al 10 investigated the impact of 2% w/w GSSG lotion on TEWL using a Corneometer (Courage + Khazaka electronic GmbH)

Baseline GSSG levels were negatively correlated with both PANSS total scores (beta = -0.369, t = -4.108, p 25%) or non-responders (reduction rate 25%) [28]