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Co-treatment with NAC led to a reduction in lipid peroxidation, nitric oxide (NO), and protein carbonyls, while maintaining levels of GSH, total antioxidant capacity, and antioxidant enzymes (GPx, GST, SOD, CAT)

5 Once steady state is reached, the washout period for AJOVY is similar for monthly and quarterly dosing (~5-6 half-lives) 6 Washout period defined as time until plasma concentrations of AJOVY are below a clinically relevant concentration and thus considered eliminated

Moreover, studies indicate that CTH-deficient GBM cells exhibit lower viability when exposed to H 2 O 2 when compared to controls

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