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If not properly validated and integrated with domain knowledge, ML-based models may produce spurious correlations rather than causal insights, leading to flawed extrapolation in drug development

Standard Treatments for Thalassemia and Their Effects Thalassemia treatment includes blood transfusions, iron chelation therapy, and folic acid to manage anemia

These factors may act synergistically amplify peripheral itch perception and contribute to the persistence and exacerbation of chronic pruritus through multiple signaling cascades, as partially illustrated in Figure 4 and in greater detail in Figure 5

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