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Koyyalamudi SR, Jeong SC, Cho KY, Pang G

CaiBYiXHanQPanJChenHSunHet al

[7] Commonly observed adverse effects include transient injection-site discomfort, breast tenderness, nausea, fluid retention, and mild mood fluctuation, whereas rarer but serious events encompass venous or arterial thromboembolism, gallbladder disease, significant elevation of blood pressure, and hormone-sensitive malignancies such as endometrial or breast cancer

Since peripheral 5-HT cannot cross the BBB, central serotonin is synthesized from Trp, which is transported through the BBB from blood circulation (170)