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muciniphila , decline pathogenic bacteria, such as Aspergillus and Trematode spirochetes , promote the production of intestinal microbial metabolites such as SCFAs, and restore the breakdown and assimilation of glycolysis, amino acid metabolism, and carbohydrates (Liao et al., 2020), rectifying the imbalance in the rat intestinal flora ratio caused by a HFD, reducing the proportion of Firmicutes to Bacteroidetes , safeguarding the intestinal mucosal barrier, improving intestinal permeability, and preventing hyperlipidemia (Zhang et al., 2012)

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Conversely, another possibility is that a lower C4B copy number might protect the stability of the host microbiome to some extent by reducing the excessive clearance of beneficial microbes mediated by C4B

Rathmann W, Kostev K