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TA uptake via GLUTs is elevated under fasting, resulting in downregulation of orexigenic neuropeptide expression in the hypothalamus To elucidate the anorexigenic effects of TA, DIO mice were administered a single i.p

Unlike allicin, which is highly reactive and rapidly interacts with thiol-containing molecules in the body too quickly to be of much benefit, this powerhouse antioxidant has high bioavailability

However, challenges related to the complexity and variety of natural product compositions must be addressed to fully realize their potential

This neurobiological shift would represent a functional change in food reward rather than a peripheral taste bud alteration, though human evidence remains limited