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For patients who have already tried GLP-1 therapy, adding an amylin pathway intervention targets different receptors and different brain regions, which is what makes the combination genuinely additive

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Expression and purification of RAMP ECD-CTR ECD fusion proteins The general expression procedure of the calcitonin receptor (CTR) extracellular domain (ECD) alone and RAMP1, -2, or -3 ECD fused with CTR ECD as functional amylin receptor ECDs was previously reported [21,23]

Further REIMAGINE results presented at the ADA meeting in June 2026 reinforced that signal across diverse patient groups