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Feature importance analysis using Recursive Feature Elimination with Cross-Validation (RFECV) selects the most influential features

It can be challenging to extrapolate results from cell or animal models to human patients due to inherent differences in biological systems

In addition to pro-inflammatory mediators secreted by activated chondrocytes, macrophages, synovial fibroblasts and subchondral bone cells undergo immunometabolic reprogramming in osteoarthritis, resulting in a shift from oxidative phosphorylation toward glycolytic metabolism to meet the increased energy demands associated with the low-grade inflammation within the joint