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Beyond the pancreas, GLP-1 receptors are expressed in the liver, adipose tissue, kidneys, and hypothalamus, which accounts for the drug class's broader effects on satiety, weight, inflammation, and renal protection.[4] The relevance to PCOS is direct: by improving insulin sensitivity and reducing hyperinsulinemia, GLP-1 receptor agonists lower the primary driver of ovarian androgen overproduction

Role of oxidative and nitrosative stress in cisplatin-induced nephrotoxicity

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While the therapeutic peptide field blew up after insulin was introduced in the 1920s, it hit a major roadblock in the 1980s due to poor stability and high production costs