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Methods Mice Mice were bred and maintained in the Alexandria Center for the Life Sciences animal facility of the New York University School of Medicine, under specific-pathogen-free conditions and were fed LabDiet standard 5053 diet before experimentation

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We mutated these SUMO-acceptor lysine resides to arginines and monitored alterations in Drp1 distribution, mitochondrial phenotypes, and cell death in NPCs to precisely investigate the role of Drp1 SUMOylation in NPCs

For all, this results in underdeveloped and/or inadequate therapeutic and diagnostic options