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[10] A chronic sleep-restricted state adversely affects the brain and cognitive function

doi: 10.1016/j.freeradbiomed.2013.07.036 19 AliSSAhsanHZiaMKSiddiquiTKhanFH

Nevertheless, the effect of butyrate on human gut mucosa and immunity is well known and is key to human health 3,5,6,43

From disrupted neurotransmitter systems to altered stress circuits and impaired reward processing, opiate withdrawal represents a profound neurological recalibration