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However, the few reports of CBD activity alone against GBM demonstrate a good response, with the concentration required to inhibit cell growth by 50% (GI 50 ) ranging from 10.67 0.58 M against GL216 [33] and 12.75 9.7 M against U87MG [34,35,36,37,38] to 21.6 3.5 M against U373MG [36]