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Br J Cancer 117(12):1874-1882, 2017

Unlike the DAC (Drug Affinity Complex) variant, it has a shorter half-life and does not exhibit prolonged receptor binding, allowing for controlled and physiologic patterns of GH secretion and reduced risk of receptor desensitization

Future studies could utilize patient-derived human pluripotent stem cells and differentiate them into T cells to decipher the mechanisms that trigger the population shift from nave T cells to other cell types, including CD8+TCF1 high cells, and determine whether these autoreactive T cells can lead to the destruction of cells using human in vitro models

They note that this provides 12 grams of extra sodium to the diet and should be enough to mitigate symptoms of weakness, fatigue and hypotension associated with hypovolemia and natriuresis