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Indeed, a small study by Gao et al (2019), involving 6 human participants, reported that a lowered dietary methionine intake may lead to a significant reduction of circulating homocysteine along with reductions in L- cysteine, N- acetyl cysteine, glutathione and a significant increase in circulating riboflavin (vitamin B 2 ) after 3 weeks

Evidence for gut microbiota involvement in anxiety disorders is consistent across human studies and strongly supported by preclinical mechanistic data, with therapeutic interventions showing early promise in randomized controlled trials, yet still requiring a large-scale validation

The decrease in antioxidant enzyme activities under As stress could be because ROS or direct interactions with As stop or break down these enzymes 42

Note that histone variants such as H2A.X, H3.3 and CENP-A may have distinct and unique modifications