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This may help readjust the balance between oxidizing factors and antioxidants in the brain

133 Because tumor cells exchange intracellular glutamate for extracellular cystine through SLC7A11, intracellular glutamate is consumed, which causes cells to absorb more Gln and activate glutaminase to supplement intracellular glutamate, making cells with high expression of SLC7A11 become Gln-dependent

It will also be proposed that several of these different vicious circles may self-assemble in ways that facilitate disease perpetuation

We chose to focus on SLC7A11 as playing a critical role in intracellular GSH levels, targeting SLC7A11 with erastin