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Table 1 presents a listing of compounds in Family 1, drawn to mimetics, and Families 2-5, drawn to antagonists, all of which have been synthesized and analyzed according to the procedures described above

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The 32-week, multicentre, double-masked, phase 2 trial also showed a more significant mean change in HbA1c (glycated haemoglobin) with CagriSema versus cagrilintide but not versus semaglutide

Structural analysis demonstrates how FOXO4-DRI exploits the unique architecture of senescent cells, where FOXO4 latches onto p53 and prevents it from executing its normal pro-apoptotic function