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Methods Experimental approach Using a random number generator (www.random.org), in a double-blind, placebo-controlled design, 75 resistance-trained males between the ages of 18 and 35 were randomly assigned to ingest L-citrulline malate, L-citrulline + GSH, or placebo while also participating in 8 weeks of resistance training

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These methods illustrate that, whereas autophagy initially protects against oxidative stress by removing damaged mitochondria, its decline in COPD is ineffective in clearing ROS, leading to dysfunction of mitochondria and apoptotic signaling [88]