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Although animal models provide a more integrated physiological context, their translational value is limited by interspecies differences in copper metabolism and the difficulty in modelling human-specific gene-environment interactions [253]

Besides, the CD38 low/- NK cells engineered by CRISPR/Cas9 system is another method to maintain NK cell function during Daratumumab therapy

Shows potential for stress reduction and mood support through HPA axis modulation [8] [9]

CEMIP, identified as an oncogene, enhances the stability and nuclear accumulation of c-Myc by inhibiting the ubiquitination of this proto-oncogene