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Initially identified as a master regulator of the antioxidant response and drug or xenobiotic detoxification, NRF2 is now known to regulate target genes involved in proteasomal and autophagic function, iron, lipid, and carbohydrate metabolism, and DNA repair (4)

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[154] Certain antioxidants like anthocyanins and xanthophylls have not shown adverse health effects, while others, such as -carotene, must be consumed cautiously

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