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However, the majority of genetic risk loci are located in the non-coding regions of the genome, and each locus has a small individual contribution to the disease phenotype, making precise localization of disease sites and mechanism parsing for AD a huge challenge (Bellenguez et al., 2022

10.1126/science.aav2588 107 LiC.FengY.WangW.XuL.ZhangM.YaoY.et al (2023)

This paper introduced a new two-step approach to perform source reconstruction using the beam-forming method, by first taking into account prior specification of channels pertaining to a brain region of interest