glutathione degradation human Is a Key Determinant of Glutathione Homeostasis Liposomal glutathione outperforms plain glutathione

R Somayaji reports grants or contracts from Cystic Fibrosis Foundation, Canadian Institutes of Health Research, University of Calgary, and Vertex Pharmaceuticals

Del Mistro G, Lucarelli P, Mller I, De Landtsheer S, Zinoveva A, Hutt M, et al

Phase-II Drug Metabolism Most of the time gives metabolite that is: More polar Non-toxic Pharmacologically inactive X = O, N, S Phenol, alcohol and carboxylic acid Amine (aliphatic and aromatic) Thiol Sometimes: Phase-II gives: Less polar conjugate: Methylated drug Acetylated drug Toxic metabolite: Some sulfate conjugates Some Acetylated metabolites

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