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403,404,405,406,407,408 These include KRAS -mutant pancreatic cancers, BRAF V600E -driven brain tumors, and STAT3-high breast cancers

Drugs mimicking this activity are already approved for other disorders

However, neuron density is not the only disadvantage mice are confronted with: the neocortex constitutes 80% of the human brain (Azevedo et al., 2009) while mice have about 20 different cortical areas, humans have more than 200 (Kaas, 1989, 2011