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Moreno MC, Campanelli J, Sande P, Senz DA, Keller Sarmiento MI, et al

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Of these, the expression of seven proteins including ASAP2, regulator of G protein signaling 14 (RGS14), MAP7 domain containing 1 (MAP7D1), interleukin 3 receptor, alpha (IL-3R), Tropomodulin 1 (Tmod1), N-ribosyldihydronicotinamide dehydrogenase quinone (NQO2), and MUP were validated by Western blot assays

This results in HIF-1 translocation into the nucleus, where in a complex with HIF-1 it activates transcription via binding to hypoxia responsive elements (HRE) in the promoters of corresponding genes (Kim et al., 2021)