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NAD+ acts as a vital cofactor for oxidoreductases

Therefore, cerebral serotonin is synthetized in the brain, where it plays a major role in mood regulation and, after transformation in melatonin, in sleep regulation (155, 156), as summarized in Figure 1

It plays a central role in: Detoxifying toxins and heavy metals Supporting immune health and inflammation balance Regenerating other antioxidants (like vitamins C and E) Maintaining mitochondrial energy production Slowing the cellular aging process A low Glutathione Index may reflect oxidative stress or a depletion of antioxidant capacity

6f and Supplementary Fig