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Symptoms of overmethylation can include: [23] Restless legs/pacing Hyperactivity High pain tolerance Histamine intolerance Sleep disorders Panic disorders Paranoia Insomnia Low libido ADHD Low motivation Depression Anxiety High levels of neurotransmitters (dopamine, norepinephrine, and serotonin) A high copper to zinc ratio Generally, undermethylation will result in symptoms more akin to depression and sluggishness, while overmethylation is usually linked to symptoms like hyperactivity and anxiety

Cleveland Clinic overview of the common causes of joint pain and when to see a medical provider is a helpful starting point for understanding when joint pain needs a fuller medical workup

It can activate both the amylin receptor and the calcitonin receptor