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In particular, the recent emergence of base and prime editing offers precise, double-strand break-free strategies to engineer these functional modifications, highlighting the ongoing evolution of genomic tools for enhanced neuronal differentiation and the potential application of CRISPR-based therapeutic approaches to improve cell replacement therapy with increased safety in the clinic 102,103

The cells were treated with increasing concentrations of erastin (Sigma-Aldrich, USA) for 24 h to induce ferroptosis and co-treated with or without 100 nM Liproxstatin-1 (Sigma-Aldrich, USA) to inhibit ferroptosis

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Spycher, P