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Therefore, increased levels of neuromelanin in medial SNc could underline its selective susceptibility to ferroptosis-related changes as a result of increased oxidative stress, compared to ventrolateral SNc

doi: 10.1038/jcbfm.2008.79 46 RezaieT.ChildA.HitchingsR.BriceG.MillerL.Coca-PradosM.et al

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This process promotes the translocation of Nrf2 to the nucleus, triggering the activation of antioxidant response elements and increasing the expression of genes involved in antioxidant defences and anti-inflammatory responses [131]